My 11 year old maltese mix started Trilostane for Cushing's Disease about two months ago. Her initial dosage was 0.5mL BID but after the first ACTH test to check that dosage, she was increased to .7mL BID. She has been exhibiting some signs of depression but we thought that may have been because of the recent birth of our baby in April. Last Friday she vomitted several times but seemed ok afterwards as far as eating and drinking. The following Monday she was sneezing and coughing, then had a seizure. All of her vitals were fine at the ER vet, but that vet said she had very red eyes and nasal passages so we cleared up the sneezing and coughing with benedryl and have not had any of it since? Bloodwork on Tuesday showed very high kidney levels- BUN at 142 and elevated creatinine and phosphorus. Her appetite is basically non-existent, but I can get her to eat some boiled chicken and steak- only protein which I know is bad for her already distressed kidneys. She has not had any vomitting or diarrhea since the initial bout last Friday, but has not had as many bowel movements as normal. My vet cannot explain the seizure, and she had two more since we brought her home Saturday from her hospitalization for fluids. Now, her mobility is compromised, insofaras, she cannot get up quickly and is very unsure on her back feet at first. She also is restless and gets up from laying down often, as if to be sure she is still in the same place, or changes positions like she is uncomfortable. Her Cushing's is pituitary derived, though no tumor was confirmed. She also has a 2k Amylase value, which no one has seemed that concerned about- just a case of pancreatitis?
My question is if she should come off trilostane completely (my vet wants to just decrease her dose to .7mL once a day) and if these neurological symptoms could be a result of her high kidney values and not because of a different issue?
